Dr. Britt Glaunsinger provides an overview of virology, and describes how the study of viruses has guided the understanding of many fundamental cellular processes, from gene expression to cancer. These insights arise from studying how viruses manipulate and hijack cellular machinery during infection and viral replication. Viruses can use the host machinery to their advantage, altering the gene expression landscape of the cell to create an environment favorable for the infection to progress. As Glaunsinger explains, one way viruses alter gene expression is by affecting the messenger RNA (mRNA) degradation process. By increasing decay of cellular messages, viruses can decrease competition for access to the translation machinery and dampen the expression of immune stimulatory elements that restrict viral replication.
View the full talk with additional resources on our website
Kaposi’s sarcoma herpes virus (KSHV) nuclease: Viral Strategies to Manipulate Gene Expression in Host Cells
Britt Glaunsinger provides an overview of virology and KSHV. She describes how the study of viruses has guided the understanding of many fundamental cellular processes, from gene expression to cancer. (Talk recorded in October 2019)
- Part 1: Viruses Reveal the Secrets of BiologyAudience:
- Student
- Researcher
- Educators
- Educators of H. School / Intro Undergrad
- Educators of Adv. Undergrad / Grad
Duration: 00:28:22 - Part 2: KSHV: Herpesviral Nucleases Impact Cellular RNA Destruction and SynthesisAudience:
- Student
- Researcher
- Educators
- Educators of H. School / Intro Undergrad
Duration: 00:34:43