In the second lecture, Dr. Matthew State overviews the hunt for genes associated with autism and explains how studying de-novo rare mutations in the germline has advanced the understanding of the genetics of autism spectrum disorder (ASD). Studying a cohort of families with one affected individual and one unaffected sibling, they were able to map multiple genes involved in ASD. Because of the complexity of the developing brain, the same gene could act upon different regions of the brain at different times during development. Therefore, after identifying genes associated with ASD, they characterized the region and time during development where these genes are expressed and more likely to have an effect that is associated with ASD.
View the full talk with additional resources on our website
Developing Autism Spectrum Disorder Therapeutics
Dr. Bryan King introduces the autism spectrum disorder (ASD), and Dr. Matthew State overviews the hunt for genes associated with autism. (Talk recorded in August 2017)
- Part 1: Developing Autism Spectrum Disorder Therapeutics: Treatment Targets and Tools from 30,000 Feet Audience:
- General Public
- Student
- Researcher
- Educators of H. School / Intro Undergrad
- Educators of Adv. Undergrad / Grad
Duration: 34:33 - Part 2: From Genes to Pathology in Autism Spectrum Disorders Audience:
- Student
- Researcher
- Educators of H. School / Intro Undergrad
- Educators of Adv. Undergrad / Grad
Duration: 34:40