Actin forms many cellular structures and regulates a variety of critical biological processes. Dr. David Drubin’s lab focuses on studying actin in the context of membrane trafficking. In his first iBiology seminar, Drubin recounts seminal research done using the intracellular pathogen Listeria that uncovered how the bacteria harnesses phagocytosis and actin polymerization to facilitate motility. These initial studies led to the discovery of key regulators of actin filament formation including Arp2/3 and N-WASP. Advances in yeast genetics, biochemistry and imaging then allowed Drubin and others to expand their studies to actin dynamics and endocytosis in yeast.
View the full talk with additional resources on our website
Actin Dynamics and Endocytosis in Yeast and Mammalian Cells
In this series of videos, Dr. David Drubin describes the critical link between actin dynamics and endocytosis in both budding yeast and mammalian cells. (Talk recorded in October 2017)
- Part 1: Introduction: Actin, Endocytosis and the Early Days of Yeast Cell BiologyAudience:
- Student
- Researcher
- Educators of H. School / Intro Undergrad
- Educators of Adv. Undergrad / Grad
Duration: 25:09 - Part 2: Actin Dynamics and Endocytosis in YeastAudience:
- Researcher
- Educators of Adv. Undergrad / Grad
Duration: 30:25 - Part 3: Actin Dynamics and Endocytosis in Mammalian CellsAudience:
- Researcher
- Educators of Adv. Undergrad / Grad
Duration: 35:12 - Part 4: Actin Assembly in Budding YeastAudience:
- Researcher
- Educators
- Educators of Adv. Undergrad / Grad
Duration: 28:37