Dr. Helen Piwnica-Worms provides a historical perspective on cell cycle regulation and outlines important experiments in frogs, clams, and yeast that revealed crucial mediators of the cell cycle. Scientists observed that there were factors that allowed cell cycle progression, while there were other factors that prevented the cell from going backward. Using these model organisms, scientists were able to characterize the activation of the inducer of mitosis, the M-Phase promoting factor, which is a heterodimer between cyclin-dependent kinase (Cdc2/Cdk1) and cyclin B.
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Cell Cycle Regulation
Helen Piwnica-Worms provides a historical perspective on cell cycle regulation and outlines important experiments that revealed crucial mediators of the cell cycle. (Talk recorded in May 2017)
- Part 1: Frogs, Clams, Yeast & Human Cancer: Historical Perspective on Cell Cycle RegulationAudience:
- Student
- Researcher
- Educators of H. School / Intro Undergrad
- Educators of Adv. Undergrad / Grad
Duration: 00:29:08 - Part 2: Translating Fundamental Cell Cycle Principles to Targeted Cancer TherapiesAudience:
- Researcher
- Educators of Adv. Undergrad / Grad
Duration: 00:29:28