Piwnica-Worms explains how scientists have used their understanding of the cell cycle regulation to generate targeted cancer therapies. The cell has proteins that serve as cell cycle checkpoints, which allows the cell to respond appropriately to DNA damage. Although not all of the checkpoints are functional in a cancer cell, these cells still need the checkpoint proteins to respond to DNA damage. Piwnica-Worms’ laboratory studies the use of combining DNA damage agents with checkpoint inhibitors to selectively kill cancer cells. Her laboratory developed a patient-derived xenograft mouse model to study Triple Negative Breast Cancer (TNBC), and predict how the genotype of the tumor affects treatment.
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Cell Cycle Regulation
Helen Piwnica-Worms provides a historical perspective on cell cycle regulation and outlines important experiments that revealed crucial mediators of the cell cycle. (Talk recorded in May 2017)
- Part 1: Frogs, Clams, Yeast & Human Cancer: Historical Perspective on Cell Cycle RegulationAudience:
- Student
- Researcher
- Educators of H. School / Intro Undergrad
- Educators of Adv. Undergrad / Grad
Duration: 00:29:08 - Part 2: Translating Fundamental Cell Cycle Principles to Targeted Cancer TherapiesAudience:
- Researcher
- Educators of Adv. Undergrad / Grad
Duration: 00:29:28