In her second lecture, Zoghbi explains how MeCP2 molecularly modulates neuronal function. Their studies uncovered a critical link between cytosine methylation, MeCP2, and the methylating enzyme Dnmt3a, in Rett Syndrome. They hypothesized that MeCP2 partially causes Rett-Syndrome symptoms by failure of reading methylated DNA marked by Dnmt3 and indeed showed that Dnmt3-dependent mCH plays a central role in Rett pathogenesis.
View the full talk with additional resources on our website
Rett Syndrome and the Insight it Provides into Syndromic Autism
Dr. Huda Zoghbi’s seminar takes us through the scientific journey from discovering the cause of Rett Syndrome to testing possible treatments for MECP2 disorders. (Talk recorded in December 2019)
- Part 1: Rett Syndrome: Genomes, Epigenomes and Neuropsychiatric conditionsAudience:
- Student
- Researcher
- Educators
- Educators of H. School / Intro Undergrad
- Educators of Adv. Undergrad / Grad
Duration: 00:33:43 - Part 2: Pathogenesis of MeCP2 DisordersAudience:
- Student
- Researcher
- Educators
- Educators of H. School / Intro Undergrad
- Educators of Adv. Undergrad / Grad
Duration: 00:26:12 - Part 3: Possible Future Therapies for Rett SyndromeAudience:
- Student
- Researcher
- Educators
- Educators of H. School / Intro Undergrad
- Educators of Adv. Undergrad / Grad
Duration: 00:27:32