Esvelt’s second talk focuses on strategies to allow for the safe implementation of localized gene drive technologies that do not spread indefinitely. Daisy drive systems are made up of multiple elements connected like a daisy chain such that each causes the next to be preferentially inherited. They are designed to be self-exhausting by losing elements with each generation, thereby limiting spread. This technique has multiple applications such as removing an invasive species from one area without impacting the same species in its native habitat. Esvelt explains that daisy-drive stability might be tested in a species such as C. elegans where hundreds of generations can be grown in a short period of time. His lab is also developing technologies to reverse any unwanted genetic changes that might be introduced via gene drive. Once again, Esvelt emphasizes the importance of community input into any gene alteration projects. Although it does not currently involve gene drive, he uses the “Mice Against Ticks” project that seeks to prevent tick-borne diseases on the islands of Nantucket and Martha’s Vineyard as an example.
View the full talk with additional resources on our website
Gene Drive
Dr. Kevin Esvelt explains how CRISPR-based gene drives can be used to spread genetic alterations through wild populations. He discusses strategies to maximize benefit and minimize risk. (Talk recorded in July 2018)
- Part 1: Gene DriveAudience:
- Student
- Researcher
- Educators of H. School / Intro Undergrad
- Educators of Adv. Undergrad / Grad
Duration: 00:25:23 - Part 2: Gene Drive and Local DriveAudience:
- Student
- Researcher
- Educators of H. School / Intro Undergrad
- Educators of Adv. Undergrad / Grad
Duration: 00:32:59