Jan characterizes the Calcium-Activated Chloride Channels (CaCC) in the TMEM16 family of transmembrane proteins with unknown functions and explains experiments from her lab that aided in the understanding of the molecular role of these channels. As she explains, one family member, TMEM16A, is typically expressed in peripheral cells and is involved in the rhythmical contraction of smooth muscles in the gastrointestinal tract. On the other hand, the TMEM16B CaCC is expressed in multiple brain regions as well as sensory neurons, like photoreceptors, and they have an inhibitory role in these cells.
View the full talk with additional resources on our website
Introduction to Ion Channels
Dr. Lily Jan defines the physiological role of ion channels, like potassium channels and Calcium-Activated Chloride Channels, in the regulation of excitability in neurons. (Talk recorded in March 2018)
- Part 1: Introduction to Ion Channels: A Close Look at the Role and Function of Potassium ChannelsAudience:
- Student
- Researcher
- Educators of H. School / Intro Undergrad
- Educators of Adv. Undergrad / Grad
Duration: 25:35 - Part 2: Calcium-Activated Chloride Channel (CaCC) in the Enigmatic TMEM16 FamilyAudience:
- Researcher
- Educators of H. School / Intro Undergrad
- Educators of Adv. Undergrad / Grad
Duration: 29:12