In his third talk, Patel explores the function of additional Hox genes in the development of crustacean body plans. Using CRISPR-Cas9 genome editing, his laboratory has characterized the expression and function of six of the nine Hox genes in Parhyale, and describes the combinatorial role of Ubx, abdA, and AbdB in the development of specialized appendages in this species, and how changes in the regulation of abdA is responsible for several morphological transitions during crustacean evolution.
View the full talk with additional resources on our website
The Role of Homeotic Genes in Development
Nipam Patel explains the effects of Hox gene deletions and how these phenotypes help us understand the manner in which Hox genes act to control the insect body plan. (Talk recorded in November 2017)
- Part 1: Patterning the Anterior-Posterior Axis: The Role of Homeotic (Hox) GenesAudience:
- Student
- Researcher
- Educators of H. School / Intro Undergrad
- Educators of Adv. Undergrad / Grad
Duration: 34:51 - Part 2: The Role of Ubx in the Development of Crustacean Body PlanAudience:
- Student
- Researcher
- Educators of H. School / Intro Undergrad
- Educators of Adv. Undergrad / Grad
Duration: 34:29 - Part 3: Homeotic (Hox) Genes and Evolution of Crustacean Body PlanAudience:
- Researcher
- Educators of Adv. Undergrad / Grad
Duration: 33:27