Dr. Norma Andrews overviews the mechanisms of cellular plasma membrane repair. As she describes, a lesion is followed by a Ca2+-dependent movement of vesicles to the plasma membrane. By studying how the Trypanosoma cruzi parasite enters the cell, Andrews’ laboratory discovered that an increase of intracellular calcium was triggering lysosomal fusion to the plasma membrane. This unexpected observation allowed them to conclude that upon an injury to the plasma membrane, a Ca2+ influx induces lysosomal exocytosis mediated repair. This research demonstrates that lysosomes are not only responsible for the degradation of material that comes inside the cell through endocytosis, but also have an important role in plasma membrane repair.
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Plasma Membrane Repair
Norma Andrews overviews the mechanisms of cellular plasma membrane repair. As she describes, a lesion is followed by a Ca2+-dependent movement of vesicles to the plasma membrane. (Talk recorded in March 2017)
- Part 1: Mechanisms of Plasma Membrane RepairAudience:
- Student
- Researcher
- Educators of H. School / Intro Undergrad
- Educators of Adv. Undergrad / Grad
Duration: 00:24:42 - Part 2: Ca2+-Dependent Lysosomal Exocytosis Mediates Endocytosis and Wound HealingAudience:
- Researcher
- Educators of Adv. Undergrad / Grad
Duration: 00:36:22