Andrews further explains how Ca2+-dependent exocytosis of lysosomes aids membrane repair. Her laboratory showed that after lysosomal exocytosis, an injury to the plasma membrane would also trigger a Ca2+-dependent endocytosis that is required for the repair mechanism. Andrews laboratory showed that lysosomes release the enzyme acid sphingomyelinase (ASM) which induce the endocytosis required for plasma membrane repair.
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Plasma Membrane Repair
Norma Andrews overviews the mechanisms of cellular plasma membrane repair. As she describes, a lesion is followed by a Ca2+-dependent movement of vesicles to the plasma membrane. (Talk recorded in March 2017)
- Part 1: Mechanisms of Plasma Membrane RepairAudience:
- Student
- Researcher
- Educators of H. School / Intro Undergrad
- Educators of Adv. Undergrad / Grad
Duration: 00:24:42 - Part 2: Ca2+-Dependent Lysosomal Exocytosis Mediates Endocytosis and Wound HealingAudience:
- Researcher
- Educators of Adv. Undergrad / Grad
Duration: 00:36:22