Dr. Randy Schekman overviews the secretory pathway and reviews historical experiments that shaped our molecular understanding of this pathway. The journey begins at the endoplasmic reticulum (ER), where proteins that engage the secretory pathway get translated. The mRNA of these proteins codes for a signal sequence that serves as a “tag” to bring the mRNA-ribosome-newly-synthesized protein to the ER for continued translation and movement of the new secretory protein across the ER membrane into the interior or lumen of the organelle. Vesicles transport the recently translated proteins to the Golgi Apparatus, where they get “packaged” and sent to their final destination.
View the full talk with additional resources on our website
Protein Secretion and Vesicle Trafficking
Protein secretion occurs via membrane vesicles that transfer proteins to the cell surface. Randy Schekman provides a genetic dissection of the protein secretion pathway in yeast. (Talk recorded in December 2016)
- Part 1: The Secretory Pathway: How Cells Package and Traffic Proteins for ExportAudience:
- Student
- Researcher
- Educators of H. School / Intro Undergrad
- Educators of Adv. Undergrad / Grad
Duration: 00:35:01 - Part 2: Genes and Proteins Required for SecretionAudience:
- Student
- Researcher
- Educators of H. School / Intro Undergrad
- Educators of Adv. Undergrad / Grad
Duration: 00:38:29 - Part 3: How Human Cells Secrete Small RNAs in Extracellular VesiclesAudience:
- Researcher
- Educators of Adv. Undergrad / Grad
Duration: 00:38:41