Schekman explains how his laboratory used baker’s yeast to uncover major proteins involved in the secretory pathway, and describes proteins involved in budding, vesicle trafficking, and vesicle fusion. Schekman also presents data from his laboratory that helped to identify the ER channel through which proteins enter the secretory pathway. These series of experiments show how, step by step, scientific knowledge evolves, uncovering the fundamental mechanisms to better understand human disease.
View the full talk with additional resources on our website
Protein Secretion and Vesicle Trafficking
Protein secretion occurs via membrane vesicles that transfer proteins to the cell surface. Randy Schekman provides a genetic dissection of the protein secretion pathway in yeast. (Talk recorded in December 2016)
- Part 1: The Secretory Pathway: How Cells Package and Traffic Proteins for ExportAudience:
- Student
- Researcher
- Educators of H. School / Intro Undergrad
- Educators of Adv. Undergrad / Grad
Duration: 00:35:01 - Part 2: Genes and Proteins Required for SecretionAudience:
- Student
- Researcher
- Educators of H. School / Intro Undergrad
- Educators of Adv. Undergrad / Grad
Duration: 00:38:29 - Part 3: How Human Cells Secrete Small RNAs in Extracellular VesiclesAudience:
- Researcher
- Educators of Adv. Undergrad / Grad
Duration: 00:38:41