Schekman outlines exosome biogenesis. Exosomes are extracellular vesicles released by the cell, and in contrast to intracellular vesicles, exosomes contain small molecules of RNA. Schekman’s laboratory characterized the RNAs contained in exosomes and showed the importance of Ybx1 protein for the recruitment of certain miRNAs into exosomes.
View the full talk with additional resources on our website
Protein Secretion and Vesicle Trafficking
Protein secretion occurs via membrane vesicles that transfer proteins to the cell surface. Randy Schekman provides a genetic dissection of the protein secretion pathway in yeast. (Talk recorded in December 2016)
- Part 1: The Secretory Pathway: How Cells Package and Traffic Proteins for ExportAudience:
- Student
- Researcher
- Educators of H. School / Intro Undergrad
- Educators of Adv. Undergrad / Grad
Duration: 00:35:01 - Part 2: Genes and Proteins Required for SecretionAudience:
- Student
- Researcher
- Educators of H. School / Intro Undergrad
- Educators of Adv. Undergrad / Grad
Duration: 00:38:29 - Part 3: How Human Cells Secrete Small RNAs in Extracellular VesiclesAudience:
- Researcher
- Educators of Adv. Undergrad / Grad
Duration: 00:38:41