Drug discovery for diseases of the nervous system is difficult. Although mouse models are helpful to study many human diseases, they have serious limitations for understanding neurological and psychiatric disease. Dolmetsch describes a method developed by his group to produce induced pluripotent stem cell-derived neurons from patients. Using these iPSC neurons, they can identify molecular defects associated with a neurodevelopmental disease and then identify medicines to treat those diseases.
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Neurodevelopmental disease: Drug Discovery in Neuroscience
Ricardo Dolmetsch tells us how neurons made from the stem cells of children with neurodevelopmental diseases can be used to make medicines to treat incurable diseases. (Talk recorded in July 2016)
Audience:
- Researcher
- Educators of H. School / Intro Undergrad
- Educators of Adv. Undergrad / Grad
Duration: 44:32