In Part 2, Walther and Farese explain in more depth how lipid droplets form in cells in an organized manner. Triglycerides and other neutral lipids are made in the ER membrane. They accumulate in localized regions of the membrane that grow towards the cytosol and eventually bud off into lipid droplets. Farese and Walther describe experiments from their lab and others that have identified a protein complex in the ER membrane called LDAF1/Seipin that regulates where triglycerides localize and grow into mature lipid droplets.
View the full talk with additional resources on our website
Lipid Droplets
All organisms have evolved ways to store energy- mostly as fat packaged into lipid droplets. Farese and Walther explain how lipid droplets form in cells and the physiological importance of getting this process right. (Talk recorded in December 2019)
- Part 1: An Introduction to Lipid DropletsAudience:
- Student
- Researcher
- Educators
- Educators of H. School / Intro Undergrad
- Educators of Adv. Undergrad / Grad
Duration: 00:08:06 - Part 2: Mechanisms of Lipid Droplet FormationAudience:
- Researcher
- Educators
- Educators of Adv. Undergrad / Grad
Duration: 00:25:11 - Part 3: Physiology of Lipid Droplet FormationAudience:
- Researcher
- Educators
- Educators of Adv. Undergrad / Grad
Duration: 00:29:16