Jan explains how dendrite morphology relates to the function of neurons. For example, class IV da neurons are photoreceptors and their dendrites form a regular array in the fruit fly larvae to enable the avoidance of noxious signals, like light. On the other hand, class III da neurons are mechanosensors, and they use no mechanoreceptor potential C (NompC) protein to detect gentle touch. Jan and collaborators showed that NompC works by tethering ankyrin repeats to microtubules, providing evidence for the first time that this type of gating mechanosensor mechanism is possible.
View the full talk with additional resources on our website
Studying the Development of Dendrite Morphogenesis
Dr. Yuh-Nung Jan outlines the sequence of events that led to the understanding of the molecular underpinnings that drive dendrite morphogenesis. (Talk recorded in March 2018)
- Part 1: How Does a Neuron Develop its Neuronal Type Specific Dendritic Morphology?Audience:
- Student
- Researcher
- Educators of H. School / Intro Undergrad
- Educators of Adv. Undergrad / Grad
Duration: 38:56 - Part 2: Dendrite Morphology and Function: Cellular and Molecular Basis of Dendrite Audience:
- Researcher
- Educators of Adv. Undergrad / Grad
Duration: 35:07