Proteins that are secreted from the cell or inserted into the plasma membrane, transit through the endoplasmic reticulum where they are properly folded and assembled and may undergo post-translational modification. Walter tells the story of the exciting discovery made in his lab of the “unfolded protein response”, a feedback pathway that ensures that the cell makes enough ER to properly modify all the secreted proteins in the cell.
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About the Speaker
Peter Walter is a Professor of Biochemistry and Biophysics at the University of California, San Francisco and a Howard Hughes Medical Institute Investigator. His lab studies how cells regulate the quantity of their organelles and how proteins localize to the right place within a cell. Walter is also a long-time co-author of “The Molecular Biology of the Cell”, one of the most widely used textbooks in the field.
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