Dr. David Bikard’s lab focuses on engineering bacteria with CRISPR to combat microbial pathogens. In this video, he introduces the historical context for using CRISPR in bacteria and then delves into two CRISPR technologies being developed by his lab. Part of his lab is using CRISPR/Cas9 to eliminate antibiotic resistance in bacterial populations. His group is also optimizing a catalytically dead Cas9 (dCas9) to modulate levels of CRISPR-induced transcriptional repression and use it in pooled high throughput screens for gene function.
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Engineering bacteria with CRISPR
David Bikard’s talk focuses on engineering bacteria with CRISPR to combat microbial pathogens. He explains how CRISPR technologies could eliminate antibiotic resistance. (Talk recorded in September 2017)
Audience:
- Researcher
- Educators of Adv. Undergrad / Grad
Duration: 34:17