In his first talk, Dr. Hans Clevers provides a historical perspective on the discovery of adult stem cells in the gut. They identified a Wnt-dependent, rapid proliferating population of cells at the bottom of the crypt which seemed to be important for generating all epithelial cells in crypts and villi, and they hypothesized that these were gut stem cells. By using the Lgr5 gene as a marker, the Clevers’ lab confirmed that these long-lived cells were indeed the gut stem cells by showing that they were able to generate all of the cell types of the gut epithelium throughout life. Clevers characterizes the gut stem cells and its progenitors, and explains how his lab developed a technique to grow from a single stem cell an organoid or mini-organ, a structure that recapitulates the normal structure of the gut.
View the full talk with additional resources on our website
Adult Stem Cells and Organoids
Dr. Hans Clevers provides a historical perspective on the discovery of adult stem cells in the gut, and explains how his lab developed a technique to grow from a single stem cell an organoid or mini-organ, a structure that recapitulates the normal structure of the gut. (Talk recorded in September 2019)
- Part 1: Discovery and Characterization of Adult Stem Cells in the GutAudience:
- Student
- Researcher
- Educators
- Educators of H. School / Intro Undergrad
- Educators of Adv. Undergrad / Grad
Duration: 00:31:35 - Part 2: Generating Epithelial Organoids from Adult TissueAudience:
- Student
- Researcher
- Educators
- Educators of H. School / Intro Undergrad
- Educators of Adv. Undergrad / Grad
Duration: 00:21:02 - Part 3: Organoid Technology for Disease ModelingAudience:
- Student
- Researcher
- Educators
- Educators of H. School / Intro Undergrad
- Educators of Adv. Undergrad / Grad
Duration: 00:32:13