In his second talk, Clevers shows how one can apply what we have learned from developing gut organoids to generate mini-organs for other epithelial tissues, like liver and lung. Clevers shows that these organoids have a similar expression profile as well as structural characteristics to those observed in real tissue. In addition, he shows how this technique can be used to generate non-mammalian organoids, like the development of venom gland organoids from snake venom gland tissue. As Clevers explains, such organoids can be used to discover possible novel therapeutics, including new anti-venom serum.
View the full talk with additional resources on our website
Adult Stem Cells and Organoids
Dr. Hans Clevers provides a historical perspective on the discovery of adult stem cells in the gut, and explains how his lab developed a technique to grow from a single stem cell an organoid or mini-organ, a structure that recapitulates the normal structure of the gut. (Talk recorded in September 2019)
- Part 1: Discovery and Characterization of Adult Stem Cells in the GutAudience:
- Student
- Researcher
- Educators
- Educators of H. School / Intro Undergrad
- Educators of Adv. Undergrad / Grad
Duration: 00:31:35 - Part 2: Generating Epithelial Organoids from Adult TissueAudience:
- Student
- Researcher
- Educators
- Educators of H. School / Intro Undergrad
- Educators of Adv. Undergrad / Grad
Duration: 00:21:02 - Part 3: Organoid Technology for Disease ModelingAudience:
- Student
- Researcher
- Educators
- Educators of H. School / Intro Undergrad
- Educators of Adv. Undergrad / Grad
Duration: 00:32:13