Dr. Shiv Pillai provides a historical perspective on the current model of how the immune system works. Scientists observed that the body produces molecules (antibodies) that recognize the entry of foreign particles (antigens). He outlines the different models of the structure and functions of antibodies and explains the process by which antibody diversity is generated during B cell development (VDJ recombination). B cell development also involves two checkpoints to ensure the generation of functional antibodies and prevent the recognition of self-structures.
View the full talk with additional resources on our website
B Cell Development, Fundamental Questions in Immunology
Shiv Pillai provides a historical perspective on the steps that led to formulate today’s model on how the immune system works and outlines the underpinnings of B cell development. (Talk recorded in March 2018)
- Part 1: Early B Cell Development: A Look at the Defining Questions in ImmunologyAudience:
- Student
- Researcher
- Educators of H. School / Intro Undergrad
- Educators of Adv. Undergrad / Grad
Duration: 00:37:30 - Part 2: Bruton Tyrosine Kinase Signaling: The pre-B Cell Receptor and B Cell DifferentiationAudience:
- Researcher
- Educators of H. School / Intro Undergrad
- Educators of Adv. Undergrad / Grad
Duration: 00:23:27 - Part 3: IgG4-Related Disease: Collaboration Between B and T CellsAudience:
- Researcher
- Educators of H. School / Intro Undergrad
- Educators of Adv. Undergrad / Grad
Duration: 00:26:54