Pillai explains IgG4-Related Disease (IgG4-RD), a chronic inflammatory condition characterized by elevated numbers of T cells and IgG4 secreting plasma cells in the affected tissue. Using tissue samples from patients with the disease, his laboratory isolated and characterized the CD4+ T cells associated with IgG4-RD. Furthermore, he explains how the crosstalk between these CD4+ T cells and B cells is important for IgG4-RD development, and showed that depletion of B cells improves the outcome of the disease.
View the full talk with additional resources on our website
B Cell Development, Fundamental Questions in Immunology
Shiv Pillai provides a historical perspective on the steps that led to formulate today’s model on how the immune system works and outlines the underpinnings of B cell development. (Talk recorded in March 2018)
- Part 1: Early B Cell Development: A Look at the Defining Questions in ImmunologyAudience:
- Student
- Researcher
- Educators of H. School / Intro Undergrad
- Educators of Adv. Undergrad / Grad
Duration: 00:37:30 - Part 2: Bruton Tyrosine Kinase Signaling: The pre-B Cell Receptor and B Cell DifferentiationAudience:
- Researcher
- Educators of H. School / Intro Undergrad
- Educators of Adv. Undergrad / Grad
Duration: 00:23:27 - Part 3: IgG4-Related Disease: Collaboration Between B and T CellsAudience:
- Researcher
- Educators of H. School / Intro Undergrad
- Educators of Adv. Undergrad / Grad
Duration: 00:26:54