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Home » Podcasts » Dan Littman Part 1: Th17 Cells and Innate Lymphoid Cells in Barrier Defense and Inflammatory Diseases

iBiology Podcast

Dan Littman Part 1: Th17 Cells and Innate Lymphoid Cells in Barrier Defense and Inflammatory Diseases

June 29, 2019

Dan Littman discusses the opposing roles of Th17 cells. They protect mucosal surfaces from infection with bacteria and fungi, but they can also cause autoimmune inflammation. Using a mouse model of autoimmunity called experimental autoimmune encephalomyelitis (EAE), Littman and his lab have shown that there are two types of Th17 cells. Non-pathogenic Th17 cells are induced by the microbiota and protect barrier surfaces, while pathogenic Th17 cells are induced by the presence of IL-23, likely the result of inflammation elsewhere in the body.  Both types Th17 cells secrete the cytokines IL-17A, IL-17F and IL-22, however, pathogenic Th17 cells also secrete interferon gamma (IFNγ) which induces further inflammation and autoimmune disease.  In the last 10 years, several classes of innate lymphoid cells have been found to share similar cytokine profiles to T helper cells and these cells appear to be another important layer in protecting surfaces in the gut and lung from infection.

View the full talk with additional resources on our website

Th17 Cells and Innate Lymphoid Cells in Barrier Defense and Inflammatory Disease

Th17 cells are important in our protective immune response and their differentiation is guided by our intestinal microbiota. Th17 cells also can exist in a pathogenic form that causes autoimmune disease. (Talk recorded in December 2017)

  • Part 1: Th17 Cells and Innate Lymphoid Cells in Barrier Defense and Inflammatory Diseases
    Part 1: Th17 Cells and Innate Lymphoid Cells in Barrier Defense and Inflammatory Diseases
    Audience:
    • Researcher
    • Educators of Adv. Undergrad / Grad
    Duration: 38:28
  • Part 2: Shaping of Immune Responses by the Microbiota
    Part 2: Shaping of Immune Responses by the Microbiota
    Audience:
    • Researcher
    • Educators of Adv. Undergrad / Grad
    Duration: 45:16

Speaker Bio

Dan Littman

Dan Littman
Dan Littman is the Helen and Martin Kimmel Professor of Molecular Immunology in the Skirball Institute of Biomolecular Medicine and in the Departments of Pathology and Microbiology of the New York University School of Medicine. He is also an Investigator of the Howard Hughes Medical Institute. Littman discovered the excitement of science while he was…

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This material is based upon work supported by the National Science Foundation and the National Institute of General Medical Sciences under Grant No. 2122350 and 1 R25 GM139147. Any opinion, finding, conclusion, or recommendation expressed in these videos are solely those of the speakers and do not necessarily represent the views of the Science Communication Lab/iBiology, the National Science Foundation, the National Institutes of Health, or other Science Communication Lab funders.

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