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Home » Podcasts » Dan Littman Part 2: Shaping of Immune Responses by the Microbiota

iBiology Podcast

Dan Littman Part 2: Shaping of Immune Responses by the Microbiota

June 29, 2019

Littman explains that different commensal microbes in our gut elicit different T cell responses – either pathogenic or non-pathogenic. His lab is beginning to identify the pathogens and decipher the pathways that determines the host T cell response. This research has important clinical relevance since a cancer patient’s microbiota may help determine their response to chemotherapy and immunotherapy. Microbiota that induce non-pathogenic Th17 cells and regulatory T cells are protective against autoimmunity but may decrease anti-tumor immunity, while microbiota that contribute to autoimmunity may enhance anti-tumor T cell responses.

View the full talk with additional resources on our website

Th17 Cells and Innate Lymphoid Cells in Barrier Defense and Inflammatory Disease

Th17 cells are important in our protective immune response and their differentiation is guided by our intestinal microbiota. Th17 cells also can exist in a pathogenic form that causes autoimmune disease. (Talk recorded in December 2017)

  • Part 1: Th17 Cells and Innate Lymphoid Cells in Barrier Defense and Inflammatory Diseases
    Part 1: Th17 Cells and Innate Lymphoid Cells in Barrier Defense and Inflammatory Diseases
    Audience:
    • Researcher
    • Educators of Adv. Undergrad / Grad
    Duration: 38:28
  • Part 2: Shaping of Immune Responses by the Microbiota
    Part 2: Shaping of Immune Responses by the Microbiota
    Audience:
    • Researcher
    • Educators of Adv. Undergrad / Grad
    Duration: 45:16

Speaker Bio

Dan Littman

Dan Littman
Dan Littman is the Helen and Martin Kimmel Professor of Molecular Immunology in the Skirball Institute of Biomolecular Medicine and in the Departments of Pathology and Microbiology of the New York University School of Medicine. He is also an Investigator of the Howard Hughes Medical Institute. Littman discovered the excitement of science while he was…

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This material is based upon work supported by the National Science Foundation and the National Institute of General Medical Sciences under Grant No. 2122350 and 1 R25 GM139147. Any opinion, finding, conclusion, or recommendation expressed in these videos are solely those of the speakers and do not necessarily represent the views of the Science Communication Lab/iBiology, the National Science Foundation, the National Institutes of Health, or other Science Communication Lab funders.

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