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Home » Podcasts » Jeannie Lee Part 1: Making and Breaking the Silence

iBiology Podcast

Jeannie Lee Part 1: Making and Breaking the Silence

June 29, 2019

In mammals, sex is determined by a pair of unequal sex chromosomes. Genetically male mammals have an X and a Y chromosome while genetically female mammals have two X chromosomes. The X chromosome is many times larger than the Y chromosome. To compensate for this genetic inequality, female mammals undergo X chromosome inactivation in which one of the X chromosomes is randomly chosen to be silenced. X chromosome inactivation has been studied for over 50 years both because it is a physiologically important event and because it is an excellent model for studying epigenetic silencing of genes by long non-coding RNAs. In her first talk, Dr. Jeannie Lee gives an overview of the steps a cell must go through during X inactivation. These include “counting” the X chromosomes, deciding which X chromosome to inactivate, initiating the inactivation and spreading it across the chromosome, and finally maintaining inactivation of the same X chromosome for the rest of the life of the organism.

View the full talk with additional resources on our website

X Chromosome Inactivation

The X chromosome is many time larger than the Y chromosome. To compensate for this genetic inequality, female mammalian cells undergo X chromosome inactivation of one X chromosome. Dr. Jeannie Lee explains the how and why of X chromosome inactivation. (Talk recorded in November 2018)

  • Part 1: Making and Breaking the Silence
    Part 1: Making and Breaking the Silence
    Audience:
    • Student
    • Researcher
    • Educators of H. School / Intro Undergrad
    • Educators of Adv. Undergrad / Grad
    Duration: 00:45:44
  • Part 2: Making the Right Choice
    Part 2: Making the Right Choice
    Audience:
    • Researcher
    • Educators of Adv. Undergrad / Grad
    Duration: 00:21:31
  • Part 3: Spreading the Silence
    Part 3: Spreading the Silence
    Audience:
    • Researcher
    • Educators of Adv. Undergrad / Grad
    Duration: 00:38:17

Speaker Bio

Jeannie Lee

Jeannie Lee
Dr. Jeannie Lee is a Professor in the Department of Genetics at Harvard Medical School and in the Department of Molecular Biology at Massachusetts General Hospital (MGH). Her lab uses X chromosome inactivation as a model to study epigenetic regulation by long noncoding RNAs. Lee received her AB in biochemistry and molecular biology from Harvard…

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This material is based upon work supported by the National Science Foundation and the National Institute of General Medical Sciences under Grant No. 2122350 and 1 R25 GM139147. Any opinion, finding, conclusion, or recommendation expressed in these videos are solely those of the speakers and do not necessarily represent the views of the Science Communication Lab/iBiology, the National Science Foundation, the National Institutes of Health, or other Science Communication Lab funders.

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