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Home » Podcasts » Jeannie Lee Part 2: Making the Right Choice

iBiology Podcast

Jeannie Lee Part 2: Making the Right Choice

June 29, 2019

Lee elaborates on the early steps of X inactivation. Very early in development, cells “count” the number of X chromosomes and decide if one needs to be inactivated, and if so which one. There is a region of the X chromosome called the X inactivation center which is enriched in long non-coding RNAs (lncRNAs). Lee explains how she and others showed that by sensing the ratio of two specific lncRNAs the cell can determine how many X chromosomes are present. Further studies showed that two different lncRNAs are responsible for randomly determining which X chromosome will be inactivated. Finally, she discusses the hypothesis that the allelic choice mechanism depends on a transient chromosomal pairing event that occurs at the beginning of the dosage compensation process.

View the full talk with additional resources on our website

X Chromosome Inactivation

The X chromosome is many time larger than the Y chromosome. To compensate for this genetic inequality, female mammalian cells undergo X chromosome inactivation of one X chromosome. Dr. Jeannie Lee explains the how and why of X chromosome inactivation. (Talk recorded in November 2018)

  • Part 1: Making and Breaking the Silence
    Part 1: Making and Breaking the Silence
    Audience:
    • Student
    • Researcher
    • Educators of H. School / Intro Undergrad
    • Educators of Adv. Undergrad / Grad
    Duration: 00:45:44
  • Part 2: Making the Right Choice
    Part 2: Making the Right Choice
    Audience:
    • Researcher
    • Educators of Adv. Undergrad / Grad
    Duration: 00:21:31
  • Part 3: Spreading the Silence
    Part 3: Spreading the Silence
    Audience:
    • Researcher
    • Educators of Adv. Undergrad / Grad
    Duration: 00:38:17

Speaker Bio

Jeannie Lee

Jeannie Lee
Dr. Jeannie Lee is a Professor in the Department of Genetics at Harvard Medical School and in the Department of Molecular Biology at Massachusetts General Hospital (MGH). Her lab uses X chromosome inactivation as a model to study epigenetic regulation by long noncoding RNAs. Lee received her AB in biochemistry and molecular biology from Harvard…

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This material is based upon work supported by the National Science Foundation and the National Institute of General Medical Sciences under Grant No. 2122350 and 1 R25 GM139147. Any opinion, finding, conclusion, or recommendation expressed in these videos are solely those of the speakers and do not necessarily represent the views of the Science Communication Lab/iBiology, the National Science Foundation, the National Institutes of Health, or other Science Communication Lab funders.

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