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Home » Podcasts » Tom Rapoport Part 2: How are cellular organelles shaped?

iBiology Podcast

Tom Rapoport Part 2: How are cellular organelles shaped?

June 29, 2019

The ER is a vast network that includes different domains with different functions. The rough ER is made of ribosome covered membrane sheets and is involved in protein translation.  The smooth ER consists of tubules and is important for lipid synthesis and Ca2+ transport. In his second talk, Rapoport explains how his lab identified several families of proteins needed to generate and maintain a tubular ER network. Using ultra-thin section microscopy, Rapoport and others also showed that stacked ER sheets are held together by helicoidal membrane connections that form a “parking-garage” like structure.

View the full talk with additional resources on our website

Protein Sorting and its Role in Organelle Function and Shape

Eukaryotic cells have many different membrane-bound organelles with distinct functions and characteristic shapes. How does this happen? Dr. Tom Rapoport explains the important role of protein sorting in determining organelle shape and function. (Talk recorded in February 2019)

  • Part 1: Organelle Biosynthesis and Protein Sorting
    Part 1: Organelle Biosynthesis and Protein Sorting
    Audience:
    • Student
    • Researcher
    • Educators of H. School / Intro Undergrad
    • Educators of Adv. Undergrad / Grad
    Duration: 00:35:01
  • Part 2: How are cellular organelles shaped?
    Part 2: How are cellular organelles shaped?
    Audience:
    • Researcher
    • Educators of Adv. Undergrad / Grad
    Duration: 00:32:29

Speaker Bio

Tom Rapoport

Tom Rapoport
Dr. Tom Rapoport has been a Professor of Cell Biology at Harvard Medical School since 1995 and a Howard Hughes Medical Institute Investigator since 1997.  Prior to joining Harvard, Rapoport was a Professor at the Institute for Molecular Biology in East Berlin, which later became the Max-Delbrück Institute for Molecular Medicine.  Rapoport received his PhD…

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This material is based upon work supported by the National Science Foundation and the National Institute of General Medical Sciences under Grant No. 2122350 and 1 R25 GM139147. Any opinion, finding, conclusion, or recommendation expressed in these videos are solely those of the speakers and do not necessarily represent the views of the Science Communication Lab/iBiology, the National Science Foundation, the National Institutes of Health, or other Science Communication Lab funders.

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