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Home » Speakers » Baldomero “Toto” Olivera
Toto Olivera

Baldomero “Toto” Olivera

University of Utah & Howard Hughes Medical Institute
National Academy of Sciences

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Baldomero “Toto” Olivera received a B.S. degree in Chemistry from the University of the Philippines, a PhD in Biophysical Chemistry from Caltech and did his postdoctoral work at Stanford University. His early research contributions included the discovery and biochemical characterization of E. coli DNA ligase.

His laboratory initiated the identification and characterization of the biologically active peptides found in the venoms of predatory cone snails.  This led to a broad involvement with molecular neuroscience, particularly the functional role of ion channels and receptor subtypes in nervous systems. The Conus peptide project has raised wide ranging biological questions, from mechanisms of protein folding and post-translational modification, to gene organization and mechanisms of speciation; several Conus peptides discovered in Olivera’s laboratory are being developed as therapeutics and one is approved as a commercial drug.

Olivera is currently a Distinguished Professor of Biology at the University of Utah and a Howard Hughes Medical Institute Professor. He is also a member of the National Academy of Sciences and the Institute of Medicine.

Talks with this Speaker

Conus Venom

There are over 700 species of venomous marine cone snails. Baldomero Olivera describes how his lab purified one conus venom and found it contained 100 neurotoxic peptides. (Talk recorded in October 2014)

  • Part 1:  Venom Complexity
    Part 1:  Venom Complexity
    Audience:
    • Student
    • Researcher
    • Educators of H. School / Intro Undergrad
    • Educators of Adv. Undergrad / Grad
    Duration: 38:56
  • Part 2: The Generation of Peptide Diversity
    Part 2: The Generation of Peptide Diversity
    Audience:
    • Researcher
    • Educators of Adv. Undergrad / Grad
    Duration: 30:31
  • Part 3: From Chemical Biology to Neuroscience
    Part 3: From Chemical Biology to Neuroscience
    Audience:
    • Researcher
    • Educators of Adv. Undergrad / Grad
    Duration: 34:01

Venomous Snails

Baldomero Olivera describes venomous cone snails and how his lab purified venom from one species and found that it contained a variety of peptide neurotoxins. (Talk recorded in October 2014)

Toto Olivera
Audience:
  • General Public
  • Student
  • Researcher
  • Educators of H. School / Intro Undergrad
  • Educators of Adv. Undergrad / Grad
Duration: 12:49

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This material is based upon work supported by the National Science Foundation and the National Institute of General Medical Sciences under Grant No. 2122350 and 1 R25 GM139147. Any opinion, finding, conclusion, or recommendation expressed in these videos are solely those of the speakers and do not necessarily represent the views of the Science Communication Lab/iBiology, the National Science Foundation, the National Institutes of Health, or other Science Communication Lab funders.

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