Dr. Xiaodong Wang gives an introduction to apoptosis. Apoptosis is a form of programmed cell death that plays important roles during animal development, immune response, elimination of damaged cells, and maintenance of tissue homeostasis. Apoptosis is executed by intracellular proteases named caspases that are activated during the onset of apoptosis by extrinsic and intrinsic pathways.
The intrinsic pathway is triggered by the release of proteins such as cytochrome c from mitochondria to cytosol and the extrinsic pathway is activated by the binding of death-inducing cytokines such as Tumor Necrosis Factor to its receptor at the cell surface. Both pathways are regulated at multiple steps to ensure proper apoptosis.
Xiaodong Wang is the Director and an Investigator of the National Institute for Biological Sciences, Beijing. Previously, Dr. Wang was a professor of biochemistry at The University of Texas Southwestern Medical Center at Dallas and an investigator of the Howard Hughes Medical Institute from 1997-2010. Wang received a bachelor’s degree in biology from Beijing Normal… Continue Reading