What do chromosomes look like in our cells? A total of two meters of DNA is packed inside a 1 micrometer tiny nucleus of each cell. How is this condensation achieved? In this 2022 Share Your Research Talk, Wang describes his research to build a mathematical model for a process called Loop Extrusion, which describes how DNA folds and forms loops at kilobase scale. This model helps us understand complex interactions between DNA fragments as well as their 3D structure. The model can be used to predict how small changes in DNA sequence disrupts higher order chromatin architecture and has implications in common genetic diseases like cancer and Alzheimer’s disease.
Wang Xi, PhD completed his doctoral program at Johns Hopkins University. At the time of filming, Wang was a PhD candidate and his thesis research focused on chromatin interactions and their implications on gene regulation through computational modeling. Wang seeks to continue doing interdisciplinary research as a postdoc at Harvard University. Continue Reading