Bertolotti describes a platform developed by her lab that has allowed them to rationally identify selective protein phosphatase inhibitors. Using this platform her lab identified a novel small molecule phosphatase inhibitor that blocks the accumulation of misfolded proteins in the cytosol or nucleus and showed the therapeutic effects of the molecule in a model of Huntington’s disease.
View the full talk with additional resources on our website
Protein Phosphatases
Kinases and phosphatases perform a balancing act in cells by adding and removing phosphate groups from proteins. Dr. Bertolotti shows us that inhibiting specific protein phosphatases can reduce misfolded protein accumulation and reduce neurodegenerative disease. (Talk recorded in January 2019)
- Part 1: A Historical Perspective on Protein PhosphatasesAudience:
- Student
- Researcher
- Educators of H. School / Intro Undergrad
- Educators of Adv. Undergrad / Grad
Duration: 00:29:15 - Part 2: Benefits of Phosphatase Inhibition for Neurodegenerative DiseasesAudience:
- Researcher
- Educators of Adv. Undergrad / Grad
Duration: 00:30:12 - Part 3: A Platform to Identify Selective Protein Phosphatase InhibitorsAudience:
- Researcher
- Educators of Adv. Undergrad / Grad
Duration: 00:34:15