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Home » Podcasts » Anne Bertolotti Part 3: A Platform to Identify Selective Protein Phosphatase Inhibitors

iBiology Podcast

Anne Bertolotti Part 3: A Platform to Identify Selective Protein Phosphatase Inhibitors

June 29, 2019

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Bertolotti describes a platform developed by her lab that has allowed them to rationally identify selective protein phosphatase inhibitors. Using this platform her lab identified a novel small molecule phosphatase inhibitor that blocks the accumulation of misfolded proteins in the cytosol or nucleus and showed the therapeutic effects of the molecule in a model of Huntington’s disease.

View the full talk with additional resources on our website

Protein Phosphatases

Kinases and phosphatases perform a balancing act in cells by adding and removing phosphate groups from proteins. Dr. Bertolotti shows us that inhibiting specific protein phosphatases can reduce misfolded protein accumulation and reduce neurodegenerative disease. (Talk recorded in January 2019)

  • Part 1: A Historical Perspective on Protein Phosphatases
    Part 1: A Historical Perspective on Protein Phosphatases
    Audience:
    • Student
    • Researcher
    • Educators of H. School / Intro Undergrad
    • Educators of Adv. Undergrad / Grad
    Duration: 00:29:15
  • Part 2: Benefits of Phosphatase Inhibition for Neurodegenerative Diseases
    Part 2: Benefits of Phosphatase Inhibition for Neurodegenerative Diseases
    Audience:
    • Researcher
    • Educators of Adv. Undergrad / Grad
    Duration: 00:30:12
  • Part 3: A Platform to Identify Selective Protein Phosphatase Inhibitors
    Part 3: A Platform to Identify Selective Protein Phosphatase Inhibitors
    Audience:
    • Researcher
    • Educators of Adv. Undergrad / Grad
    Duration: 00:34:15

Speaker Bio

Anne Bertolotti

Anne Bertolotti
Dr. Anne Bertolotti’s research focuses on understanding and preventing the deposition of misfolded proteins in cells, a hallmark of numerous neurological diseases. Bertolotti has been a group leader at the MRC Laboratory of Molecular Biology in Cambridge, UK since 2006. Prior to joining the LMB, she was an Associate Professor at Ecole Normale Superieure in…

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This material is based upon work supported by the National Science Foundation and the National Institute of General Medical Sciences under Grant No. 2122350 and 1 R25 GM139147. Any opinion, finding, conclusion, or recommendation expressed in these videos are solely those of the speakers and do not necessarily represent the views of the Science Communication Lab/iBiology, the National Science Foundation, the National Institutes of Health, or other Science Communication Lab funders.

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