Dr. Wendell Lim explains that many signaling proteins are built from simple modules arranged in different ways. Some modules are catalytic and transmit information (e.g., kinase or phosphatase domains), while others are interaction modules that regulate information flow (e.g., protein-protein interaction domains). By rearranging these modules, Lim’s lab has reprogrammed signaling pathways to generate novel cell behavior. They are now working to use these techniques to develop cell-based therapies.
Wendell Lim is a Professor in the Department of Cellular and Molecular Pharmacology and Director of the Center for Systems and Synthetic Biology at the University of California, San Francisco. He is also a Howard Hughes Medical Institute Investigator. George Cachianes has been teaching biotechnology at Abraham Lincoln High School in San Francisco for over… Continue Reading